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Food dyes and sodium benzoate affect children's behavior
Food additives and hyperactive behaviour in 3-year-old and 8/9-year-old children in the community: a randomised, double-blinded, placebo-controlled trial

Background

We undertook a randomised, double-blinded, placebo-controlled, crossover trial to test whether intake of artificial food colour and additives (AFCA) affected childhood behaviour.

Methods

153 3-year-old and 144 8/9-year-old children were included in the study. The challenge drink contained sodium benzoate and one of two AFCA mixes (A or B) or a placebo mix. The main outcome measure was a global hyperactivity aggregate (GHA), based on aggregated z-scores of observed behaviours and ratings by teachers and parents, plus, for 8/9-year-old children, a computerised test of attention. This clinical trial is registered with Current Controlled Trials (registration number ISRCTN74481308). Analysis was per protocol.

Findings

16 3-year-old children and 14 8/9-year-old children did not complete the study, for reasons unrelated to childhood behaviour. Mix A had a significantly adverse effect compared with placebo in GHA for all 3-year-old children (effect size 020 [95% CI 001039], p=0044) but not mix B versus placebo. This result persisted when analysis was restricted to 3-year-old children who consumed more than 85% of juice and had no missing data (032 [005060], p=002). 8/9-year-old children showed a significantly adverse effect when given mix A (012 [002023], p=0023) or mix B (017 [007028], p=0001) when analysis was restricted to those children consuming at least 85% of drinks with no missing data.

Interpretation

Artificial colours or a sodium benzoate preservative (or both) in the diet result in increased hyperactivity in 3-year-old and 8/9-year-old children in the general population.

Affiliations

a. School of Psychology, Department of Child Health, University of Southampton, Southampton, UK

b. School of Medicine, Department of Child Health, University of Southampton, Southampton, UK

c. Department of Paediatrics, Imperial College, London, UK

Corresponding Author InformationCorrespondence to: Prof Jim Stevenson, School of Psychology, Faculty of Medicine, Health and Life Sciences, University of Southampton, Southampton SO17 1BJ, UK

Summary and full text available at http://www.thelancet.com/journals/lancet/article/PIIS0140673607613063/abstract.

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